Endocrine Abstracts

Objective: to evaluate the effects of metformin use on weight loss, improvement of ovarian and thyroid function in obese women with polycystic ovarian syndrome.Material and Methods: 30 obese (BMI 30–34.99 kg/m2) hypothyroid (TSH 6–10 mIU/ml) women of age 25–35 years old were included. The patients received appropriate levothyroxine treatment according to TSH levels and body weight. A number of 15 patients added metformin gradual...

Introduction: Parathyroid adenomas are the main cause of primary hyperparathyroidism. They are usually small – weighing <1 g – and not easy to find – requiring meticulous imaging studies for localisation. Giant adenomas are uncommon; large tumours and high levels of PTH raise the suspicion of parathyroid malignancy.Case presentation: A 68-year-old female presented in our clinic with polydipsia, poliuria, nausea, weight loss, and extrem...

We present the case of a 51 years old woman, nonsmoker, without relevant past medical history, who presented with acute psychotic state starting the third day of treatment with prednisone 30 mg indicated for allergy. She had also arterial hypertension and a significant and progressive loss of proximal muscle strength in her legs. The initial evaluation showed hyperglycemia, metabolic alkalosis and severe hypokalemia. Basal plasma cortisol was high (>90 μg/dl) and did ...

Introduction: Paraneoplastic Cushing’ syndrome (CS) represents 5–10% of all CS and has a severe prognosis due to severe metabolic imbalance, denutrition, associated infections, and progression of tumoural underlying pathology.A 67 years old woman presented with mental confusion, progressive weight loss, severe oedema and kypokalaemia, without typical features of Cushing or hyperpigmentation. Investigations revealed paraneoplastic Cushing’s...